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Search Results for " sphingosine kinase 1 "

ターゲット

Apoptosis S1P Receptor Autophagy LPL Receptor

阻害剤

天然化合物

1733

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T8840	PF-543 hydrochloride	PF-543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T12436	PF-543 Citrate	Sphingosine Kinase 1 Inhibitor II Citrate	S1P Receptor
	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).		S1P Receptor
T9992	SphK1&2-IN-1		S1P Receptor
	SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.		S1P Receptor
T63047	SLP9101555		S1P Receptor , LPL Receptor
	SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace...		S1P Receptor , LPL Receptor
T27710	K6PC-5	K6PC5,K6PC 5	S1P Receptor
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ...		S1P Receptor
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T8461	SKI V		Apoptosis , PI3K , S1P Receptor
	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity		Apoptosis , PI3K , S1P Receptor
T24803	SKI 5C	SKI5C,SKI-5C
	SKI 5C is a selective inhibitor of Sphingosine Kinase 1.
T70816	(R)-FTY720-OMe
	(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
T83883	Biotin Sphingosine	Biotinyl Sphingosine
	Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates.
T12927	SK1-IN-1		S1P Receptor
			S1P Receptor
T70071	SLM6031434 (free base)
	SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.
T70613	SLP120701 HCl
	SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Interv...
T71393	(S)-FTY-720 Vinylphosphonate
	(S)-FTY-720 Vinylphosphonate inhibits sphingosine kinase 1 and promotes its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer cells, and androgen-independent prostate cancer cells.
T70614	SLR080811 HCl
	SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h...
T70900	VT-ME6
	VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residu...
T70704	RB-005
	RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradat...
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitivel...
T35781	Sphinganine (d20:0)	Sphinganine (d20:0)
	Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1...
T37548	Azido-FTY720	azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survi...

Compounds

PF-543

T6085

Synonym: Sphingosine Kinase 1 Inhibitor II,PF 543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

PF-543 hydrochloride

T8840

Synonym: PF-543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

PF-543 Citrate

T12436

Synonym: Sphingosine Kinase 1 Inhibitor II Citrate

Target: S1P Receptor, LPL Receptor

K6PC-5

T27710

Synonym: K6PC5,K6PC 5

Target: Apoptosis, S1P Receptor

SKI V

T8461

Synonym:

Target: Apoptosis, PI3K, S1P Receptor

SKI 5C

T24803

Synonym: SKI5C,SKI-5C

Synonym: Biotinyl Sphingosine

SLM6031434 (free base)

(S)-FTY-720 Vinylphosphonate

Synonym: Sphinganine (d20:0)

Target:

azido-FTY720

T37548

Synonym: azido-FTY720

Target:

カタログ番号	製品名	別名	ターゲット
T38262	Sphingosine (d14:1)
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fu...

天然物製品

Sphingosine (d14:1)

T38262

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04432	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
TMPY-04431	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-02112	FGFR4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-00322	DEC-205 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp...
TMPY-02779	Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)	Human	Baculovirus Insect Cells
	Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)	Human	HEK293 Cells
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in devel...
TMPY-04529	EGFR Protein, Human, Recombinant (aa 668-1210, His & GST)	Human	Baculovirus Insect Cells
	EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.1 kDa and the accession number is P00533-1.
TMPY-04261	CD64 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD64 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is P12314-1.
TMPY-01147	R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.
TMPY-00464	M-CSF/CSF1 Protein, Mouse, Recombinant	Mouse	HEK293 Cells
	M-CSF/CSF1 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P07141-1.
TMPY-02412	ENO1 Protein, Human, Recombinant (His)	Human	E. coli
	ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1.
TMPY-01920	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin S Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P25774-1.
TMPY-06074	B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is A0A2K5U6P5-1.
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
TMPY-03956	Fas Ligand Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells su...
TMPY-00414	LILRA5/CD85f/ILT11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LILRA5/CD85f/ILT11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is A6NI73-1.
TMPY-01082	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His)	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession num...
TMPY-06076	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.7 kDa and the accession number is Q8N149-1.
TMPY-03967	BTN3A3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BTN3A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is O00478-1.
TMPY-02154	FAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FAP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q12884-1.
TMPY-00756	FGF-1 Protein, Human, Recombinant	Human	E. coli
	FGF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is P05230-1.
TMPY-05201	Siglec-2/CD22 Protein, Human, Recombinant	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 75.2 kDa and the accession number is P20273-1.
TMPY-05827	PD-L2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 48.93 kDa and the accession number is Q9BQ51-1.
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
TMPY-05354	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is P10747-1.
TMPY-00820	IgG1 Fc Protein, Human, Recombinant (C103S)	Human	HEK293 Cells
	IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1.
TMPY-02312	CSF3R/G-CSFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CSF3R/G-CSFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q99062-1.
TMPY-05220	TSLP Protein, Human, Recombinant (R127A & R130S, His)	Human	HEK293 Cells
	TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1.
TMPY-03273	IL-18 Protein, Mouse, Recombinant	Mouse	E. coli
	IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.
TMPY-01410	IL-3R alpha/CD123 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-3R alpha/CD123 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P26951-1.
TMPY-01573	SIRP alpha Protein, Human, Recombinant (G75A, His)	Human	HEK293 Cells
	SIRP alpha Protein, Human, Recombinant (G75A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P78324-1.
TMPY-03782	Albumin Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	Albumin Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 66.4 kDa and the accession number is P02768-1.
TMPY-01968	CD32A Protein, Human, Recombinant (167 His, His)	Human	HEK293 Cells
	CD32A Protein, Human, Recombinant (167 His, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P12318-1.
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-00843	IL-25/IL17E Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-01209	IL-7R alpha/CD127 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-7R alpha/CD127 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P16871-1.
TMPY-01349	ICAM-1/CD54 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
TMPY-02591	SDF-1 Protein, Human, Recombinant	Human	E. coli
	SDF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.6 kDa and the accession number is P48061-1.
TMPY-00742	EGFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EGFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is P00533-1.
TMPY-03215	FLT3 Ligand Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
TMPY-00694	Carbonic Anhydrase 12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
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